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Joseph O'Brien Running Horses at Kentucky Downs
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Mark Thurman Scholarship Established at U of A
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Sometimes You Just Have to Thank the Universe
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Set Piece Returns to Pimlico for BWI Turf Cup
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Superb Horseman James Delahooke Dies at 77
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Tattersalls Online Sept Sale Catalogue Released
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All Eyes On Doncaster
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Former Chair of CHRB Mancini Passes Away
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33 Stakes on Tap For Aqueduct Fall Meet
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k cameron earned an easy $3500 last night in the nz trotting derby. sometimes you see horses lining up in those races that have no chance,just to get the starting money. Horses that do that are often given mentally and physically draining runs and you wonder why they bother. But kyle cameron seemed to have it sussed. He went 400m ,not sure why he restrained his horse,but it seemd to resent it a wee bit and galloped and the horse settled about 40m behind the field. So cameron completed a lap,eased it down and pulled it up. As he came off the track i guess he was thinking,i wish i could earn $3500 that easy every week. Talking about drives. the last couple of weeks have seen some very aggressive driving. It must be hard on some horses to be driven that way,but it makes for exciting racing. personally i think the 2 best drivers were the ricky may drive on spirit downunder and the mark purdon drive on arafura last night. may could have gone with john dunn on scrunch when he applied the prssure so far from home,but instead he realised the finsihing post was at the end of the straight and he nursed his horse and it responded really well for him when scrunch hit the wall with 200m to go. Actually,it was no surprise scrunch got beaten last night as he was backing up on such a hard run.Thats the thing about betting. On recent racing scrunch would have won last nights race easy,but when they have been driven so har just a week before you know it will take a toll,you just don't know how much. The arafura drive. Mark purdon used his cunningness to recognise they had gone too hard early,yet if he made a mid race move he would have gone too soon.So he waited,knowing he was positioned to capitalise onthe others up front,who had gone too soon,getting tired. i didn't back either of them myself,but i thought they were the 2 best drives of the last couple of weeks. -
By Wandering Eyes · Posted
Coteau Grove Farms' Little Miss Curlin dueled on the front end and drew away late to win the $100,000 Donovan L. Ferguson Memorial Stakes Nov. 21 at Fair Grounds Race Course, giving freshman sire Charlatan his first black-type stakes winner.View the full article -
Agree , but you can't beat a piss up & a party for sustained genuine involvement in the sport ... the racing world can learn a lot from us! -
By Wandering Eyes · Posted
All this week, the TDN has been trying to nail down concrete details surrounding the studies performed for the Racing Medication & Testing Consortium's (RMTC) Scientific Advisory Committee (SAC) into the way metformin behaves in Thoroughbreds. It turns out that the first of the three papers stemming from this study was published Wednesday in the online journal, Drug Testing and Analysis. In short, the study finds a “prolonged detection time” for the drug. This first study involved 12 Thoroughbreds aged between two and seven years of age. It was broken into two phases. In phase one, six of these horses were given an oral administration of 15 grams of metformin, while the other six were given an intravenous administration of 5 milligrams per kilogram of metformin. When metformin was no longer detectable in the blood and urine of these 12 horses, phase two began, which saw the horses given opposite treatments. It took 21 days for the metformin to fall below the limit of quantification (LOQ), set at 0.25?ng/mL for all 12 horses given both the intravenous and oral administrations. It took 11 days post-administration for the metformin concentrations to fall below the 0.25?ng/mL level in six of the 12 horses. The maximum concentration of metformin detected in this study was 941 nanograms per milliliter at around the 51 minute mark. The paper also points out that Metformin concentrations in urine “fluctuated significantly” between and within individual horses, “and there was not a consistent relationship between blood and urine samples across time points.” Interestingly, the study points out that following oral administration of the drug, “five horses showed mild signs of abdominal discomfort, such as pawing and rolling 4?[hours] after the drug was administered; these signs resolved on their own within 2?[hours].” Starting in June of last year, the RMTC performed an initial review of the existing scientific literature on the drug, then gathered together a team of researchers who performed a three-part study. The result was a recommended Minimum Reporting Level (MRL) of 4.0 nanograms per milliliter in blood. Because of metformin's erratic elimination behavior in urine, the researchers haven't recommend using it as a suitable testing matrix. Prior to that, federal regulators had used a much lower screening limit of 0.5 nanograms per milliliter in blood and 1 nanogram per milliliter in urine. And prior to that, they had used an approach allowing each individual lab's limit of detection which varied from facility to facility. Two more papers are being submitted for publication. And how much did this whole endeavour cost? That's currently unclear. When asked, a Horseracing Integrity and Welfare Unit (HIWU) spokesperson wrote the following: “The cost of the metformin studies was covered as part of the pre-established annual laboratory credit with UC Davis for science and research that is applied to California's assessment for HISA. This is determined by HISA, HIWU, UC Davis, and the CHRB. HISA and HIWU did not contribute additional funding beyond the established credit. “The credits enable Program laboratories–in this case, UC Davis–to perform timely and relevant research on behalf of the ADMC Program on an ongoing basis. These costs fall under the “Lab Testing” portion of HISA's budget, which covers all of the Program laboratories.” The post First Metformin Study Shows Drug Has “Prolonged Detection Time” appeared first on TDN | Thoroughbred Daily News | Horse Racing News, Results and Video | Thoroughbred Breeding and Auctions. View the full article
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